Diazepam

Diazepam is a drug of the benzodiazipene group with a wide range of application in medical practice; it’s included in the WHO Model List of Essential Medicines.

The drug has sedative, hypnotic, anti-anxiety, anticonvulsant, muscle relaxant and amnestic effects.  Diazepam enhances the effect of sleeping pills, narcotic, neuroleptic, analgesic drugs, alcohol. Long-term use of this drug and drugs of the benzodiazipene group can lead to addiction. 

Before ordering diazepam in our pharmacy, you should consult with your doctor to clarify all possible side effects and contraindications.

How does Diazepam works?

The mechanism of action of diazepam is associated with an increase in the inhibitory effect of gamma-aminobutyric acid on the central nervous system. The muscle relaxant effect of the drug is also due to the inhibition of spinal reflexes.

Diazepam is very quickly absorbed into the bloodstream. With oral administration, the maximum concentration of the active substance in the blood plasma is reached already within 90 minutes. Diazepam binds to plasma proteins and crosses the placental barrier, soaks into the cerebrospinal fluid, and it is excreted with breast milk.

How to use Diazepam?

Diazepam is available in different forms, such as: pills, solutions for intravenous and intramuscular administration, tablets. When ordering diazepam in our pharmacy, you can choose a convenient dosage form and dosage.

The drug is administered orally, intravenously, intramuscularly or rectally in strict accordance with the prescriptions of the attending physician. The daily dose varies from 500 μg to 60 mg of the active substance and it is calculated for each patient individually, depending on the specificity and severity of the disease, contraindications and possible side effects.

What contraindications Diazepam has?

Diazepam is a broad-spectrum drug with a massive effect on human body, it has a number of contraindications, including: hypersensitivity to the active substance and other benzodiazepine derivatives, severe myasthenia gravis, shock, angle-closure glaucoma, severe chronic obstructive pulmonary diseases, as well as a history of addiction (narcotic, alcoholic, except for the treatment of alcohol withdrawal symptoms and delirium).

Diazepam should be taken with caution by patients with severe depression, and by patients with renal or hepatic insufficiency.

With high doses of drugs and long duration of treatment, there is a risk of drug dependence; especially among patients with alcohol or drug abuse. Diazepam should not be taken for a long time unless otherwise directed. Abrupt discontinuation of treatment is unacceptable due to the risk of "withdrawal syndrome".

Before ordering diazepam in our pharmacy, you should consult with your doctor to determine the appropriate treatment regimen and dosage of the drug.